Yes, assuming that the investor's 180-day period to invest gains has not lapsed, they can still invest in 2022 and generally receive (1) a deferral of the invested gain until the earlier of December 31, 2026, and an inclusion event, and (2) an exclusion of future gain on the Qualified Opportunity Fund (QOF) interest, if they hold the QOF interest for at least 10 years. By investing after December 31, 2021, the investor misses out on a third potential OZ benefit, the permanent exclusion of 10% of their deferred gain (assuming that they would have held the QOF interest for at least five years). As an example, if the investor invests $100 and is subject to a 20% tax rate in 2026, they will pay an additional $2.00 of taxes in 2026 (10% * $100 * 20%).