You can qualify for each program separately and combine the benefits. There is some question as to the interaction between QOZs and QSBS if you pull off both successfully. There's the idea of a QOF being a QSB, and a QOZB being a QSB. Depending on your interpretation, there are possibly differing consequences in each scenario. What's certainly cool is that your QOF can do a Section 1045 exchange if it has QSBS. This could potentially allow you to keep the 10-year timer going while switching investments.